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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA4
All Species:
21.82
Human Site:
S619
Identified Species:
32
UniProt:
O75676
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75676
NP_001006945.1
772
85606
S619
A
S
G
Q
G
G
Q
S
Q
A
A
E
I
M
C
Chimpanzee
Pan troglodytes
XP_508900
901
98668
S748
A
S
G
Q
G
G
Q
S
Q
A
A
E
I
M
C
Rhesus Macaque
Macaca mulatta
XP_001114877
772
85557
S619
A
S
G
Q
G
G
Q
S
Q
A
A
E
I
M
C
Dog
Lupus familis
XP_854926
772
85603
S620
A
S
G
Q
G
G
Q
S
Q
A
A
E
I
M
C
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
S619
A
S
G
Q
G
G
Q
S
Q
A
A
E
I
M
C
Rat
Rattus norvegicus
Q63531
735
82865
V581
P
C
Y
T
A
N
F
V
A
P
E
V
L
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
T549
H
D
K
S
L
T
C
T
N
A
V
E
I
M
K
Chicken
Gallus gallus
Q5F3L1
789
89022
T622
Q
D
K
S
L
T
C
T
S
A
L
E
I
M
K
Frog
Xenopus laevis
P10665
733
82620
V579
P
C
Y
T
A
N
F
V
A
P
E
V
L
K
R
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
R590
V
A
P
E
V
L
M
R
Q
G
Y
D
A
A
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
A831
D
D
V
D
H
S
A
A
A
H
H
E
L
R
K
Honey Bee
Apis mellifera
XP_395099
910
102507
R651
G
S
P
D
L
A
T
R
I
R
A
G
E
I
D
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
E598
F
H
A
R
S
R
Q
E
S
A
T
E
I
M
Q
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
N592
D
P
S
I
S
K
S
N
S
A
S
D
I
M
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
W321
H
D
K
A
A
D
W
W
S
V
G
I
L
L
Y
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
T527
T
K
T
V
D
W
W
T
L
G
I
L
L
Y
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.4
98.6
96.7
N.A.
95.8
41.3
N.A.
56
64
41
41.9
N.A.
27
45.1
48.1
48.2
Protein Similarity:
100
85.6
98.9
98
N.A.
96.7
60.6
N.A.
71.6
78.4
59
60.3
N.A.
38.9
60.1
64.3
61.8
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
26.6
26.6
0
13.3
N.A.
6.6
13.3
33.3
20
P-Site Similarity:
100
100
100
100
N.A.
100
6.6
N.A.
33.3
33.3
6.6
33.3
N.A.
20
20
40
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.6
37.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
32
7
7
7
19
7
7
7
19
57
38
0
7
7
0
% A
% Cys:
0
13
0
0
0
0
13
0
0
0
0
0
0
0
38
% C
% Asp:
13
25
0
13
7
7
0
0
0
0
0
13
0
0
7
% D
% Glu:
0
0
0
7
0
0
0
7
0
0
13
57
7
0
7
% E
% Phe:
7
0
0
0
0
0
13
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
32
0
32
32
0
0
0
13
7
7
0
0
0
% G
% His:
13
7
0
0
7
0
0
0
0
7
7
0
0
0
0
% H
% Ile:
0
0
0
7
0
0
0
0
7
0
7
7
57
7
0
% I
% Lys:
0
7
19
0
0
7
0
0
0
0
0
0
0
13
25
% K
% Leu:
0
0
0
0
19
7
0
0
7
0
7
7
32
7
0
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
57
0
% M
% Asn:
0
0
0
0
0
13
0
7
7
0
0
0
0
0
0
% N
% Pro:
13
7
13
0
0
0
0
0
0
13
0
0
0
0
0
% P
% Gln:
7
0
0
32
0
0
38
0
38
0
0
0
0
0
7
% Q
% Arg:
0
0
0
7
0
7
0
13
0
7
0
0
0
7
13
% R
% Ser:
0
38
7
13
13
7
7
32
25
0
7
0
0
0
0
% S
% Thr:
7
0
7
13
0
13
7
19
0
0
7
0
0
0
0
% T
% Val:
7
0
7
7
7
0
0
13
0
7
7
13
0
0
0
% V
% Trp:
0
0
0
0
0
7
13
7
0
0
0
0
0
0
0
% W
% Tyr:
0
0
13
0
0
0
0
0
0
0
7
0
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _